apalutamide will decrease the extent or outcome of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with prescription drugs which have been CYP3A4 substrates can result in lower exposure to these prescription drugs.Smoking dra… Read More